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战斗力 鹅
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注册时间 2020-2-17
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叶绿体也许能帮人抗衰老。
最近nature上发表了一篇很有意思的研究，就是给人体细胞“充电”。
我们知道ATP是人体的能量货币，一旦出现问题了，可能会导致许多病理过程。
有没有好的办法？科学家想到了植物光合作用是一个提供能量的好办法，于是他们就决定合成人工细胞器，也就是把叶绿体的类囊体植入到动物细胞里，最终让动物细胞也拥有叶绿体的力量。
然后光照的时候，唤醒这个“叶绿体”，于是就开始对动物细胞进行修复。
这样，就一定程度上可以解决衰老的问题。
作者：李雷
https://www.zhihu.com/pin/1584281562866221057
论文：
https://www.nature.com/articles/s41586-022-05499-y
A plant-derived natural photosynthetic system for improving cell anabolism
Pengfei Chen，Xin Liu，Chenhui Gu，Peiyu Zhong，Nan Song，Mobai Li，Zhanqiu Dai，Xiangqian Fang，Zhaoming Liu，Jianfeng Zhang，Ruikang Tang，Shunwu Fan，Xianfeng Lin
AbstractInsufficient intracellular anabolism is a crucial factor involved in many pathological processes in the body1,2. The anabolism of intracellular substances requires the consumption of sufficient intracellular energy and the production of reducing equivalents. ATP acts as an ‘energy currency’ for biological processes in cells3,4, and the reduced form of NADPH is a key electron donor that provides reducing power for anabolism5. Under pathological conditions, it is difficult to correct impaired anabolism and to increase insufficient levels of ATP and NADPH to optimum concentrations1,4,6,7,8. Here we develop an independent and controllable nanosized plant-derived photosynthetic system based on nanothylakoid units (NTUs). To enable cross-species applications, we use a specific mature cell membrane (the chondrocyte membrane (CM)) for camouflage encapsulation. As proof of concept, we demonstrate that these CM-NTUs enter chondrocytes through membrane fusion, avoid lysosome degradation and achieve rapid penetration. Moreover, the CM-NTUs increase intracellular ATP and NADPH levels in situ following exposure to light and improve anabolism in degenerated chondrocytes. They can also systemically correct energy imbalance and restore cellular metabolism to improve cartilage homeostasis and protect against pathological progression of osteoarthritis. Our therapeutic strategy for degenerative diseases is based on a natural photosynthetic system that can controllably enhance cell anabolism by independently providing key energy and metabolic carriers. This study also provides an enhanced understanding of the preparation and application of bioorganisms and composite biomaterials for the treatment of disease.
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发表于 2022-12-9 10:32
我要跟星白一起光合成
